A case of malignant peritoneal mesothelioma showed complete remission with chemotherapy

Japanese Journal of Clinical Oncology
H ItoY Suzuki

Abstract

A 71-year-old woman presented with an abdominal mass and ascites and was subsequently admitted to our hospital in June 1995. Further examination revealed that the mass was malignant and, as a result, surgery was indicated. However, the mass demonstrated widespread peritoneal dissemination, which therefore could not be resected, and pathological findings suggested a malignant peritoneal mesothelioma. The patient showed a remarkable response to combined chemotherapy with an accompanying intraperitoneal injection of cisplatin and etoposide and an intravenous injection of caffeine. However, owing to side effects, this regimen was discontinued. The patient was administered a combination drug of uracil and tegafur (UFT) in addition to intraperitoneal injection of cisplatin as an outpatient. By the 223rd day after surgery, the tumor mass and ascites had completely disappeared according to the CT. Hence chemotherapy was judged to have resulted in complete remission. Such a marked response to chemotherapy is rare in an advanced malignant peritoneal mesothelioma such as the present case. Eight months later, the tumor recurred in the pleura. Another regimen of chemotherapy with cisplatin and CPT-11 was performed. However, this treatment p...Continue Reading

Citations

Jun 12, 2002·Current Treatment Options in Oncology·C F Verschraegen
Jul 28, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ryota HamaFumio Itoh
Feb 12, 2002·Seminars in Oncology·Karim FizaziNicholas J Vogelzang
Aug 2, 2000·Gastrointestinal Endoscopy·D WengrowerE Goldin
Nov 1, 2007·Journal of Digestive Diseases·Nikolaos S SalemisEfstathios Tsohataridis
Dec 17, 2009·Internal Medicine·Masatoshi NomuraRyoichi Takayanagi
Aug 14, 2001·Journal of Clinical Gastroenterology·A TandarL Stolbach

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