A case of membranoproliferative glomerulonephritis developed over twenty years with three different findings of renal pathology

CEN Case Reports
Yoshikatsu KanekoIchiei Narita

Abstract

A 31-year-old woman with proteinuria, hypocomplementemia, rheumatoid factor, and high serum polyclonal IgM concentration was admitted to our hospital for renal biopsy. She had a past history of two renal biopsies. When she was 12 years old, she developed proteinuria, microscopic hematuria, and hypocomplementemia. She was diagnosed as having 'IgM nephropathy' based on minor glomerular abnormalities as determined by light microscopy and IgM and C3 deposition in the mesangial region by immunofluorescence microscopy at the first biopsy. Despite corticosteroid treatment, her proteinuria did not improve and she discontinued regular outpatient checkups. When she was 29 years old and pregnant, she developed preeclampsia and, after delivery, a second renal biopsy was implemented. She was diagnosed as having progressed 'IgM nephropathy' with endotheliosis induced by preeclampsia. She was treated with angiotensin II receptor blocker and her proteinuria diminished; however, 1 year after the delivery, she developed proteinuria again, along with microscopic hematuria and hypocomplementemia. A third renal biopsy was conducted at 31 years of age and she was diagnosed as having membranoproliferative glomerulonephritis (MPGN) type I on the basis...Continue Reading

References

Aug 1, 1990·Clinical and Experimental Immunology·M MiyazakiY Nomoto
Sep 1, 1988·Kidney International·W A Border
Feb 1, 1995·Kidney International·H G Rennke
Jan 29, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Juhani MyllymäkiAmos Pasternack
Nov 13, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Bassam Alchi, David Jayne
Aug 16, 2011·Seminars in Nephrology·Sanjeev Sethi, Fernando C Fervenza

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