A case of membranoproliferative glomerulonephritis and AA amyloidosis complicated with pulmonary nontuberculous mycobacterial infection

CEN Case Reports
Kiyokazu TsujiShigeru Kohno

Abstract

A 75-year-old man was diagnosed with pulmonary nontuberculous mycobacterial (NTM) infection in February 2005 and was treated with rifampicin, ethambutol, and clarithromycin. However, the infection was resistant to treatment, and his chest radiograph showed an abnormality that gradually seemed to aggravate. The patient's sputum was positive for Mycobacteria. Moreover, the patient had dyspnea and an underlying chronic inflammation in the lungs. He visited our hospital because of dyspnea and leg edema in June 2011. Laboratory evaluation on admission revealed proteinuria (6 g/day) and decreased serum total protein (5.8 g/dL) and albumin (1.6 g/dL) levels, indicating nephrotic syndrome. Percutaneous renal biopsy revealed membranoproliferative glomerulonephritis (MPGN) in the acute stage and AA amyloidosis of mild degree. AA amyloidosis was also diagnosed histologically on gastric and colonic biopsy, in addition to renal biopsy. His renal function decreased gradually, and therefore, he underwent hemodialysis therapy in January 2012. However, his gastrointestinal-related symptoms persisted, and his appetite diminished, because of which he had become severely malnourished; he died 8 months later. This is a rare case of a patient with t...Continue Reading

References

Feb 1, 1995·Kidney International·H G Rennke
Jun 8, 2007·The New England Journal of Medicine·Helen J LachmannPhilip N Hawkins
Dec 14, 2011·Kidney International·Sanjeev SethiRichard J H Smith
Oct 3, 2012·Nature Reviews. Nephrology·Andrew S Bomback, Gerald B Appel
Oct 12, 2012·Clinical and Experimental Nephrology·Hitoshi YokoyamaUNKNOWN Committee for the Standardization of Renal Pathological Diagnosis and for Renal Biopsy and Disease Registry of the Japanese

❮ Previous
Next ❯

Citations

Dec 29, 2020·International Journal of Clinical Practice·Samuel DeshayesSophie Georgin-Lavialle

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antitubercular Agents (ASM)

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Antitubercular Agents

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

Related Papers

Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
Zen IsobeMasahiko Kurabayashi
Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
Nariyuki ShinozukaIkko Hashizume
© 2022 Meta ULC. All rights reserved