PMID: 11321821Apr 27, 2001Paper

A case of metachronous multiple primary lung cancers coexistent with atypical adenomatous hyperplasia

Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
H HaraH Yoshimura

Abstract

A seventy-year-old woman was admitted for an abnormal chest shadow on a routine radiograph. She had undergone left upper lobectomy with mediastinal lymph node resection (R2a) for lung cancer (stage I), eight years before. We diagnosed this cancer as well differentiated papillary adenocarcinoma, and it coexisted with a focus of atypical adenomatous hyperplasia (AAH) in the resected material. We had been following up this patient with chest radiography, CT scanning, and tumor marker tests, but eight years after her first operation, we found a small nodular lesion in the left upper field (S6). This nodule was not diagnosed with fiberoptic bronchoscopy. Because we could not exclude primary lung cancer or intrapulmonary metastasis (eight years ago), we performed partial lung resection on the left S6 nodule. Histopathologically, the diagnosis was well differentiated papillary adenocarcinoma of the lung, coexisting with a small hyperplastic focus in the resected material. It was very difficult to diagnose whether these two cancers were metachronous multiple primary lung cancers, or one primary and its intrapulmonary metastasis. In a retrospective study, an immunohistochemical examination employing Ki-67, PCNA, p 27 and p 53 was perfor...Continue Reading

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Related Papers

Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
Masafumi YamaguchiKeizo Sugimachi
Lung Cancer : Journal of the International Association for the Study of Lung Cancer
K DohmotoJ Takahara
Lung Cancer : Journal of the International Association for the Study of Lung Cancer
K SuzukiK Nagai
Kyobu geka. The Japanese journal of thoracic surgery
Mitsutaka KadokuraM Nonaka
© 2021 Meta ULC. All rights reserved