A case of micronodular pneumocyte hyperplasia diagnosed through lung biopsy using thoracoscopy

Respiration; International Review of Thoracic Diseases
Kazunori FujitakaKouki Inai


We present a case of a 39-year-old woman with sporadic tuberous sclerosis (TSC), whose chest radiograph demonstrated bilateral diffuse nodular shadowing. A transbronchial lung biopsy specimen revealed the possibility of multiple atypical adenomatous hyperplasia (AAH), which had not been reported in TSC. Thoracoscopic lung biopsy was, therefore, performed. The specimens revealed the characteristic histological and immunohistochemical features of micronodular pneumocyte hyperplasia, which has been reported as an extremely rare pulmonary manifestation of TSC. In addition, no evidence of AAH or any other pulmonary involvements of TSC including lymphangioleiomyomatosis were detected in biopsy specimens obtained at thoracoscopy.


Jun 8, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Takuo HayashiKuniaki Seyama
Aug 14, 2008·Respirology : Official Journal of the Asian Pacific Society of Respirology·Yoshihiro KobashiMikio Oka
Apr 6, 2006·Internal Medicine·Hiroyuki KamiyaTakeshi Fujii
Feb 25, 2005·AJR. American Journal of Roentgenology·Ross L RistagnoCris A Meyer
Jan 20, 2004·Pediatric Pulmonology·M P VicenteM Medina
Jul 17, 2007·Revue des maladies respiratoires·T Urban

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