PMID: 22333380Feb 16, 2012Paper

A case of Mikulicz's disease complicated by malignant lymphoma: a postmortem histopathological finding

Internal Medicine
Takeshi UeharaEiji Hara

Abstract

A 66-year-old Japanese man with an 11-year history of Mikulicz's disease (MD) received continuous corticosteroid administration. At age 58, a left renal pelvic mass was identified and diagnosed as an IgG4-related inflammatory pseudotumor. The patient underwent an operation to remove the tumor. Subsequently, he contracted repeated pulmonary infections and eventually died of severe gastrointestinal bleeding. Autopsy revealed systemic lymph node swelling and infiltration in some organs, and diffuse large B-cell lymphoma (DLBCL) was diagnosed. These findings suggest that an IgG4-related disease can be causally related to the development of malignant lymphoma through the occurrence of mucosa-associated lymphoid tissue lymphoma.

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Citations

Feb 16, 2012·Internal Medicine·Motohisa YamamotoYasuhisa Shinomura
Dec 30, 2014·World Journal of Surgical Oncology·Yiwei WangJianming Guo
Dec 30, 2017·Virchows Archiv : an International Journal of Pathology·Jacob R BledsoeJudith A Ferry
Jan 3, 2013·The Journal of Rheumatology·Sheetal PatelElliot D Rosenstein
Nov 2, 2018·Medical Molecular Morphology·Juliana Campos PinheiroPedro Paulo de Andrade Santos
Oct 24, 2018·Cell Communication and Signaling : CCS·Yao Mawulikplimi AdzavonXuemei Ma

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