A case of multiple endocrine neoplasia type 2B

Japanese Journal of Clinical Oncology
M OhtaT Mitomi

Abstract

A sporadic case of multiple endocrine neoplasia type 2B in a twenty-six year old man who manifested medullary thyroid carcinoma, multiple mucosal neuromas of the tongue and a marfanoid habitus is reported. At the time of diagnosis, he also had multiple liver and lung metastases. Genetic analysis of his lymphocytes revealed a point mutation in exon 16 of the RET proto-oncogene. Since multiple endocrine neoplasia type 2B has a relatively poor prognosis because of the occasional aggressive behavior of medullary thyroid carcinoma, the necessity of the genetic diagnosis of multiple endocrine neoplasia in the early stage is suggested.

References

Nov 2, 1978·The New England Journal of Medicine·K GrazeS Reichlin
Aug 1, 1976·American Journal of Clinical Pathology·J A CarneyS G Sheps
Mar 1, 1975·Cancer·G C ChongL H Woolner
Apr 1, 1992·International Journal of Oral and Maxillofacial Surgery·M E SchenbergP C Reade
Aug 1, 1968·The Journal of Clinical Endocrinology and Metabolism·G F DonahowerJ B Hazard
Oct 1, 1970·Metabolism: Clinical and Experimental·K E MelvinJ R Givens
Aug 30, 1973·The New England Journal of Medicine·H J WolfeA H Tashjian
Jan 1, 1966·The Journal of Pathology and Bacteriology·E D Williams, D J Pollock
Feb 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·K M CarlsonH Donis-Keller

❮ Previous
Next ❯

Citations

May 18, 2001·Surgical Oncology·N C Lee, J A Norton

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Polyendocrine Syndromes

This feed focuses on a rare genetic condition called Autoimmune Polyendocrine Syndromes, which are characterized by autoantibodies against multiple endocrine organs. This can lead to Type I Diabetes.