Abstract
Some children with profound and long-standing hypothyroidism present with signs of paradoxical sexual maturation. In females, it is characterized by breast development, vaginal bleeding, lack of pubic hair, and delayed bone age. A case of multiple ovarian cysts in a prepubertal girl with severe hypothyroidism due to autoimmune thyroiditis is reported. A 7-year, 8-month-old girl presented with precocious puberty and vaginal bleeding. A pelvic ultrasound revealed markedly enlarged ovaries with numerous cysts which disappeared dramatically after thyroid replacement. When large multiple ovarian cysts with vaginal bleeding are found in a prepubertal girl who has a retarded bone age, the possibility of associated hypothyroidism should be considered. Health care providers should keep this in mind because this constellation of symptoms can be completely reversed with the initiation of thyroid replacement.
References
Apr 1, 1976·Journal of Steroid Biochemistry·W C Adams, D M Senseman
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·K J KollerR T Zoeller
May 1, 1988·Clinical Endocrinology·P J PringleC G Brook
Feb 1, 1997·Journal of Pediatric and Adolescent Gynecology·C M GordonM R Laufer
Sep 1, 1957·The Journal of Endocrinology·A M MANDL
Citations
Feb 20, 2008·Pediatric Radiology·Lorna P BrowneR Paul Guillerman
Sep 6, 2007·Indian Journal of Pediatrics·C K IndumathiMadhuri Patil
Nov 21, 2007·Thyroid : Official Journal of the American Thyroid Association·Annalisa PanicoGiovanni Lupoli
Aug 1, 2013·Indian Journal of Human Genetics·Latha Magatha SnehaJulius Xavier Scott
May 24, 2011·Journal of Pediatric and Adolescent Gynecology·Kaci L DurbinMeredith B Loveless
May 25, 2010·Journal of Pediatric and Adolescent Gynecology·Nancy PanBrenda Kohn
Aug 1, 2009·Journal of Pediatric and Adolescent Gynecology·S E BartonM R Laufer
Jan 8, 2009·Pediatric Blood & Cancer·Andrea HunoldHans-Joachim Wagner
May 30, 2006·Journal of Pediatric and Adolescent Gynecology·Jo T Vanwinter
Jul 27, 2005·Medical Hypotheses·Anthony J YunJohn D Doux
Jul 26, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Adriana B CampanerTsutomu Aoki
Jan 15, 2013·Orvosi hetilap·László SágodiLászló Barkai
Nov 9, 2007·Annales d'endocrinologie·E LivadariuA Beckers
Dec 16, 2011·European Journal of Endocrinology·E Baranowski, W Högler
Mar 16, 2007·The Journal of Clinical Endocrinology and Metabolism·Ginny L RyanDeborah L Segaloff
Sep 26, 2006·Journal of Pediatric Endocrinology & Metabolism : JPEM·Yuthika SharmaP S N Menon
Apr 30, 2017·Experimental and Therapeutic Medicine·Shanshan ZhangGeli Liu
Jun 12, 2013·Pediatrics·Debika Nandi-MunshiCraig E Taplin