A case of neonatal alloimmune neutropenia associated with anti-human neutrophil antigen-1a (HNA-1a) antibody.

Journal of Korean Medical Science
Tae Hee HanKyou Sup Han

Abstract

Neonatal alloimmune neutropenia (NAN) is an uncommon disease of the newborn provoked by the maternal production of neutrophil-specific alloantibodies, whereby neutrophil IgG antibodies cross the placenta and induce the destruction of fetal neutrophils. Affected newborns are usually identified by the occurrence of bacterial infections. The most frequent antigens involved in NAN are the human neutrophil antigen-1a (HNA-1a), HNA-1b, and HNA-2a. We report a neonate who was delivered at 36 weeks and had a severe neutropenia but who responded well to recombinant human granulocyte colony-stimulating factor (rhG-CSF). Anti-HNA-1a antibody was identified by mixed passive hemagglutination assay in both the sera of the baby and the mother. The baby had HNA-1a and HNA-1b but the mother had only HNA-1b on granulocytes. This is the first Korean report of NAN in which the specificity of the causative antibody was identified.

References

Dec 1, 1994·The Journal of Pediatrics·M M GilmoreD N Korones
Sep 6, 2000·Transfusion Medicine·G F Lucas, P Metcalfe
Jan 15, 2002·Transfusion Medicine Reviews·David Stroncek
Dec 13, 2002·Acta Paediatrica. Supplement·A MaheshwariD A Calhoun
Jun 18, 2004·Vox Sanguinis·D Stroncek

❮ Previous
Next ❯

Citations

Sep 22, 2012·Journal of Pediatric Hematology/oncology·Sofia ÁguedaHercília Guimarães
May 3, 2019·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Leendert Porcelijn, Masja de Haas

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping
PCR

Related Concepts

Related Feeds

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.