A case of non-Hodgkin's lymphoma-associated pemphigus foliaceus and use of rituximab for treatment

The Journal of Dermatological Treatment
Edward M Prodanovic, Neil J Korman

Abstract

Pemphigus foliaceus (PF), an autoimmune skin disorder resulting in the formation of superficial blisters, is a rarely reported skin manifestation of non-Hodgkin's lymphoma (NHL). Typical therapies for PF in non-malignant cases include immunosuppressants such as corticosteroids. We report the case of a patient undergoing therapy for NHL who subsequently developed PF which resolved following treatment with rituximab, an anti-CD20 monoclonal antibody. A 73-year-old Caucasian male who received a course of rituximab for NHL 3 years prior, presented with atypical urticarial lesions that developed into blisters. Pathological determination identified the lesions as PF. Traditional corticosteroid therapy failed to resolve the PF lesions. However, in this clinical situation, the patient responded to a repeat rituximab administration with complete resolution of the PF lesions. Paraneoplastic pemphigus, the most serious form of pemphigus, is more commonly associated with malignancies, such as NHL, whereas PF is seen in non-malignant cases. Although our patient was undergoing therapy for a malignancy, the less severe pemphigus emerged and responded to a non-traditional therapy. As such, we recommend that consideration is given to alternativ...Continue Reading

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Citations

Sep 18, 2009·Annals of the New York Academy of Sciences·Enno SchmidtDetlef Zillikens
Apr 11, 2013·Immunologic Research·Francesco CasoAndrea Doria
Jul 31, 2013·Actas dermo-sifiliográficas·M Yuste Chaves, P Unamuno Pérez

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