Abstract
We report on an exceedingly rare case of noninvasive ductal carcinoma arising in malignant phyllodes tumor of the breast. The patient was a 75-year-old woman who presented with a chief complaint of an indolent tumor mass of the left breast. Papillotubular carcinoma was diagnosed by aspiration cytology, and mastectomy with preservation of the pectoral muscle was subsequently performed (Bt+Ax+Ic, R2). Histopathological examination showed proliferation of monotonous, uniform tumor cells in a cribriform pattern amid atypical and spindle-shaped cells. Neither stromal invasion of the epithelial tumor cells nor clear transition between epithelial tumor cells and non-epithelial tumor cells was seen. Immunohistochemical staining revealed that the epithelial component was positive for antibodies such as CEA, EMA and keratin, while the non-epithelial component was negative for the same antibodies. Malignant phyllodes tumor with a noninvasive ductal carcinoma was diagnosed rather than true carcinosarcoma of the breast. No metastasis was detected in the axillary lymph nodes, and the patient was classified as stage II A (T2N0M0). Although neither chemoendocrine therapy nor irradiation was employed postoperatively, no recurrence was observed ...Continue Reading
References
May 1, 1997·Pathology·V PadmanabhanG Bennett
Feb 17, 1998·Virchows Archiv : an International Journal of Pathology·R NishimuraK Mukai
Oct 3, 2000·Cancer·A W ChaneyK K Hunt
Jun 26, 2001·Postgraduate Medical Journal·S J Parker, S A Harries
Feb 15, 2002·The Breast Journal·M PandeyK M Nair
Oct 12, 2002·American Journal of Clinical Pathology·Gary M K TseThomas C Putti
Apr 15, 2003·The Journal of Pathology·Elinor J SawyerAndrew M Hanby
May 14, 2003·Virchows Archiv : an International Journal of Pathology·Takahide KodamaYasunori Okada
Aug 6, 2003·Critical Reviews in Oncology/hematology·Jonathan I Epstein
Dec 17, 2004·World Journal of Surgical Oncology·Jeremy R ParfittAlan B Tuck
Apr 29, 2005·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Nahomi TokudomeFujio Kasumi
Citations
Sep 26, 2007·Topics in Magnetic Resonance Imaging : TMRI·Asako MiyakoshiYoshimi Anzai
Aug 11, 2007·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Tomoharu SugieYukihiro Kono
May 25, 2013·Journal of Radiology Case Reports·Adam SingerMonica Yepes
Aug 7, 2014·Journal of Natural Science, Biology, and Medicine·Prithwijit Ghosh, Kaushik Saha
May 26, 2011·Surgical Oncology·Parham Khosravi-Shahi
Dec 17, 2015·Journal of Clinical Pathology·Eliza I-Lin SinBenita Kiat Tee Tan
Oct 31, 2012·Korean Journal of Pathology·Yoomi ChoiSo Yeon Park
May 18, 2016·International Journal of Surgery Case Reports·Sharat ChopraMaurizio Brotto
Nov 10, 2009·Human Pathology·Stephan Macher-GoeppingerSebastian Aulmann
Dec 15, 2010·Pathology Research International·Mardiana Abdul AzizGrace Callagy
Jun 10, 2006·Expert Review of Anticancer Therapy·J Michael Dixon
Mar 1, 2011·Oncology Letters·Yoshinori NioRiruke Maruyama
Feb 28, 2018·Annals of the Royal College of Surgeons of England·S-A LuiC W Chan
Apr 14, 2016·Oncology Letters·D I WuZhimin Fan