A case of pancreatic mixed acinar-neuroendocrine carcinoma successfully diagnosed with endoscopic ultrasound-guided fine needle aspiration.

Clinical Journal of Gastroenterology
Fumitaka NiiyaMasatsugu Nagahama

Abstract

Mixed acinar-neuroendocrine carcinoma (MAEC) of the pancreas is a rare entity, and obtaining a preoperative diagnosis is difficult. We report a case of pancreatic MAEC successfully diagnosed with EUS-FNA. The case was a 72-year-old male with upper abdominal pain. Abdominal CT showed an irregular, hypovascular tumor of pancreatic tail. EUS-FNA was performed using a 22G needle. Immunostaining revealed positive results for the acinar marker trypsin and the neuroendocrine markers chromogranin A and synaptophysin. The possibility for MAEC was considered. He underwent distal pancreatectomy and splenectomy. Immunohistochemical examination of the tumor cells showed a wide range of positivity for bcl-10 and trypsin as well as for chromogranin A and synaptophysin, but negative results for CA19-9 and AFP. Considering that ≥ 30% tumors were positive for both acinar and neuroendocrine markers, the patient was diagnosed with MAEC.

References

Aug 22, 2000·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·T OgawaT Yabana
Sep 12, 2000·Applied Immunohistochemistry & Molecular Morphology : AIMM·M SkacelW H Henricks
Jun 8, 2001·Internal Medicine·N MizunoT Hayakawa
Nov 2, 2004·Virchows Archiv : an International Journal of Pathology·Nobuyuki OhikeGünter Klöppel
Oct 16, 2008·The American Journal of Gastroenterology·Hiroshi ImaokaYoshikazu Kinoshita
May 13, 2010·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Won Jung ChungMoon-Gyu Lee
Dec 19, 2013·Case Reports in Medicine·Onyekachi Henry OgbonnaMuhammad Wasif Saif
Dec 1, 2013·Clinical Journal of Gastroenterology·Yusuke KanemasaTsunekazu Hishima
Nov 11, 2017·Diagnostic Cytopathology·Caitlin Alexander, Zahra Maleki

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