A case of posterior reversible encephalopathy syndrome in a child with myelodysplastic syndrome following allogenic bone marrow transplantation

Pediatric Hematology and Oncology
Seonhee HeoIn-sang Jeon

Abstract

Posterior reversible encephalopathy syndrome (PRES) is an uncommon but distinctive clinical-radiologic entity characterized by headache, seizures, visual disturbance, and altered mental function associated with reversible white matter edema affecting the posterior parietal and occipital lobes of the brain. Although PRES is caused by a variety of conditions, acute elevation of blood pressure, fluid retention, and treatment with immunosuppressive drugs and/or anti-neoplastic agents are the main causes. A few cases of PRES associated with hematopoietic stem cell transplantation (HSCT) in children have been reported. Early recognition of PRES and appropriate management are needed to reduce the risk of permanent neurologic disability. The authors report a case of PRES in a girl who received an HLA-identical sibling bone marrow transplantation for myelodysplastic syndrome to emphasize the importance of early recognition and institution of appropriate management of PRES during HSCT.

References

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Citations

Oct 21, 2016·Acta Neurologica Scandinavica·N TambascoA Verrotti
May 4, 2013·Pediatric Clinics of North America·Ranjit S ChimaSonata Jodele
Jan 17, 2016·NMR in Biomedicine·C J GalbánB D Ross
Dec 17, 2015·Molecular Neurobiology·Sheng ChenJianmin Zhang
Apr 12, 2015·Journal of Child Neurology·Márcio TavaresSusana Pereira
Jul 6, 2021·Case Reports in Psychiatry·Terence TumentaTolu Olupona

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The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

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