A case of pure red cell aplasia associated with angioimmunoblastic T-cell lymphoma.

Cancer Research and Treatment : Official Journal of Korean Cancer Association
Jung-Hye ChoiIle-Kyu Park

Abstract

Pure red cell aplasia is a bone marrow failure characterized by a progressive normocytic anemia and reticulocytopenia without leucopenia and thrombocytopenia. It is associated with various hematologic diseases. However, pure red cell aplasia with angioimmunoblastic T cell lymphoma has rarely been reported. Here we describe a 43-year-old woman with pure red cell aplasia associated with angioimmunoblastic T-cell lymphoma. She had severe anemia (hemoglobin 6.9 g/dL) and a low reticulocyte count (0.2%). Direct and indirect Coombs' tests were positive. A CT scan of the abdomen revealed marked hepatosplenomegaly and small multiple lymphadenopathies. A bone marrow biopsy revealed focal infiltration of abnormal lymphoid cells and absence of red cell precursors. Splenic biopsy was compatible with angioimmunoblastic T-cell lymphoma. Ultimately, diagnosis of pure red cell aplasia associated with angioimmunoblastic T-cell lymphoma was made. After initiating CHOP therapy, the patient achieved complete remission, which was accompanied, shortly thereafter, by a rise in hemoglobin levels which finally returned to normal.

References

Jun 1, 1994·American Journal of Hematology·J W LynchR S Weiner
Jun 5, 2003·British Journal of Haematology·Ahmet DoganChara Kyriakou
Oct 22, 2003·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·M DjaldettiH Bessler

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Citations

Dec 17, 2014·Journal of Clinical and Experimental Hematopathology : JCEH·Futoshi IiokaHitoshi Ohno
May 18, 2012·TheScientificWorldJournal·Efthymia VlachakiIoannis Klonizakis
Aug 13, 2013·World Journal of Clinical Oncology·Jin TaoBin Wu
Sep 3, 2020·World Journal of Clinical Oncology·Teiko KawahigashiEri Tanaka

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