A case of radiation-induced sternal malignant fibrous histiocytoma treated with neoadjuvant chemotherapy and surgical resection.

World Journal of Surgical Oncology
Bulent KocerUnal Sakinci

Abstract

Primary sternal malignant fibrous histiyocytoma (MFH) is highly rare. Effective treatment modality is surgical resection with wide margins. However, to date, the effects of radiotherapy or chemotherapy has not been clearly defined. Herein, we aimed to present a 50-year old female patient with MFH occurred in the radiotherapy field who had had surgical procedure for breast cancer 19 years ago and had followed by radiotherapy. Neoadjuvant chemotherapy was applied for MFH due to cardiac and mediastinal vascular invasion. Wide resection was carried out for the mass after having been decreased in size following neoadjuvant chemotherapy. Neoadjuvant chemotherapy was an effective method. In planning the surgical resection, the size of the tumor before chemotherapy should be considered as the initial size and surgical margins should be determined accordingly.

References

Jun 1, 1986·The Annals of Thoracic Surgery·R M KingP E Bernatz
Aug 1, 1980·The Surgical Clinics of North America·P Stelzer, W A Gay
Jan 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·N MartiniR J Ginsberg
May 1, 1948·Cancer·W G CAHAN, H Q WOODARD

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Citations

Apr 20, 2014·World Journal of Surgical Oncology·Guo-Bin ZhangJun-Ting Zhang
Mar 20, 2015·Journal of Clinical Pathology·Kanapon PradniwatPuay Hoon Tan
Feb 13, 2020·BMJ Case Reports·Joshua KongLydia Choi
Aug 12, 2021·EFORT Open Reviews·Olga SavvidouPanayiotis J Papagelopoulos

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Methods Mentioned

BETA
surgical resection
dissection
biopsy

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