PMID: 18186244Jan 12, 2008Paper

A case of relapsed small-cell lung cancer successfully treated by administration of amrubicin

Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
Hidenori Mori, Haruhito Tanaka

Abstract

Cardiotoxicity is a known adverse reaction of high cumulative doses of anthracycline drugs. We encountered a case successfully treated without myocardial disorder. A 54-year-old man who had been given a diagnosis of small-cell lung cancer (SCLC) (extensive disease) was treated with cisplatin (CDDP) plus irinotecan (CPT-11) as first-line chemotherapy, followed by amrubicin (AMR) (30 mg/m2) for 3 consecutive days against the relapsed SCLC. The cumulative dose reached 1110 mg/m2. This case report suggests that repeated treatment with AMR may be effective for relapsed SCLC.

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