PMID: 9181252May 1, 1997Paper

A case of renin-producing juxtaglomerular tumor: effect of ACE inhibitor or angiotensin II receptor antagonist

Blood Pressure
H KashiwabaraS Katayama

Abstract

We report a case of a renin-producing juxtaglomerular cell tumor and the effects of angiotensin-converting enzyme (ACE) inhibitor captopril or angiotensin II receptor antagonist TCV-116. A 19-year-old female visited our clinic because of hypertension (162/122 mmHg). Plasma renin activity (PRA) was 25 ng/ml/h and plasma aldosterone concentration (PAC) was 880 pg/ml. Abdominal sonography revealed a low echoic tumor in the center of the right kidney. The mass was shown to have isodensity on a computed tomography scan, iso- or slightly lower intensity on T1-weighted magnetic resonance imaging (MRI), and low intensity on T2-weighted MRI. Renal angiography disclosed a hypovascular tumor. Plasma renin activity was not decreased in response to oral administration of captopril (50 mg) or TCV-116 (4 mg), which is associated with a marked decrease in PAC and blood pressure. The average of the mean blood pressure determined by an ambulatory monitoring system every hour for 24 h was lowered from 118 +/- 10.6 (SD) to 85 +/- 11.4 mmHg by TCV-116. Plasma renin activity did not show any difference between the right and left renal vein. Removal of the tumor successfully decreased PRA to 0.3 ng/ml/h and PAC to 33 pg/ml, resulting in a decrease in...Continue Reading

References

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Citations

Aug 10, 2006·Néphrologie & thérapeutique·Francis DucretMadeleine Vincent
Nov 13, 2001·Obstetrics and Gynecology·N L Henderson, R C Mason
Aug 21, 2001·Hypertension Research : Official Journal of the Japanese Society of Hypertension·A TanabeH Toma
Mar 25, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Takafumi OkuraJitsuo Higaki
Jul 19, 2008·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Ivan PedrosaNeil M Rofsky
Nov 13, 2008·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·E D M GalleryJ F Mahony
Aug 29, 2009·Seminars in Ultrasound, CT, and MR·Maryellen R M Sun, Ivan Pedrosa
Jan 5, 2002·American Journal of Clinical Pathology·S A MartinJ C Cheville
Jan 15, 2008·Journal of Hypertension·Lara WongLaurence Katznelson
Oct 16, 2016·Journal of the Renin-angiotensin-aldosterone System : JRAAS·J M van RooyenA E Schutte

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