Abstract
Focal segmental glomerulosclerosis (FSGS) is associated with various clinicopathological conditions, including hypertension. We report here a case of secondary FSGS associated with malignant hypertension. A 33-year-old man with a 1-month history of visual impairment and headache visited the Department of Ophthalmology at our hospital and was found to have hypertensive retinopathy and severe hypertension (230/160 mmHg). He was referred to our department based on suspected renal dysfunction. His blood pressure on admission was 250/130 mmHg. Physical examination and laboratory tests revealed hypertensive cardiac dysfunction, focal brain edema, renal dysfunction (serum creatinine, Cr 7.07 mg/dl, blood urea nitrogen, BUN 49.9 mg/dl), massive proteinuria (10.7 g/day), and thrombotic microangiopathy. Funduscopy showed exudate, hemorrhage, and papilledema. The cause of secondary hypertension could not be identified. He was treated for primary malignant hypertension, but required hemodialysis 3 days after admission due to anuria. Treatment with antihypertensive agents resulted in the gradual recovery of renal function, although heavy proteinuria continued with nephrotic syndrome. Renal biopsy performed 1 month after admission showed fea...Continue Reading
References
Dec 12, 1992·Lancet·J M HarveyD G Beevers
Jul 1, 1992·Kidney International·M Nagata, W Kriz
Jun 1, 1989·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·H G Rennke, P S Klein
Apr 1, 1994·Kidney International·H G RennkeD L Mendrick
Jan 27, 1996·Lancet·R ThadhaniR Colvin
Jan 1, 1996·Kidney & Blood Pressure Research·W KrizK V Lemley
Jun 1, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A M Alkhunaizi, A Chapman
Mar 21, 1998·Virchows Archiv : an International Journal of Pathology·T ShimokamaT Watanabe
Jun 26, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·D BhowmikA K Dinda
Jan 30, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Vivette D D'AgatiJ Charles Jennette
Mar 23, 2004·Journal of the American Society of Nephrology : JASN·Alexandre Hertig, Eric Rondeau
Jul 14, 2004·Contributions to Nephrology·Atsuhiro IchiharaL Gabriel Navar
Jul 31, 2004·Journal of the American Society of Nephrology : JASN·Dierk H Endemann, Ernesto L Schiffrin
May 5, 2006·Current Hypertension Reports·Raghu V Durvasula, Stuart J Shankland
Jun 7, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Bassam AlchiFumitake Gejyo
May 26, 2007·The American Journal of Pathology·Koichi SuzukiHiroshi Kawachi
Sep 6, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Toshihiko ImakiireSoichiro Miura
Nov 9, 2007·Kidney International·V D D'Agati
Sep 24, 2008·Biochemical and Biophysical Research Communications·Yohei IkezumiMakoto Uchiyama
Dec 17, 2008·Current Opinion in Nephrology and Hypertension·Peter V HauserGiovanni Camussi
Dec 18, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rana HijaziCarolyn L Abitbol
Mar 6, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Toshio OgiharaUNKNOWN COLM study investigators
Mar 6, 2009·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Daniel E HenaoAngela P Cadavid
Aug 19, 2009·Clinical and Experimental Nephrology·Koichi MatsumotoTakayuki Fujita
Jan 7, 2011·Journal of the American Society of Nephrology : JASN·Yiping Wang, David C H Harris
Oct 12, 2011·Current Opinion in Critical Care·Paul E Marik, Racquel Rivera
Feb 10, 2012·American Journal of Hypertension·Tadashi SofueAkira Nishiyama