A Case of Severe Chronic Active Epstein-Barr Virus Infection with Aplastic Anemia and Hepatitis

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
Ja In LeeSeung Kew Yoon

Abstract

Epstein-Barr virus (EBV) causes various acute and chronic diseases. Chronic active EBV infection (CAEBV) is characterized by infectious mononucleosis-like symptoms that persist for more than 6 months with high viral loads in peripheral blood and/or an unusual pattern of anti-EBV antibodies. Severe CAEBV is associated with poor prognosis with severe symptoms, an extremely high EBV-related antibody titer, and hematologic complications that often include hemophagocytic lymphohistiocytosis. However, CAEBV which led to the development of aplastic anemia (AA) has not been reported yet. A 73-year-old woman was admitted to our hospital with intermittent fever, general weakness and elevated liver enzymes. In the serologic test, EBV-related antibody titer was elevated, and real-time quantitative-PCR in peripheral blood showed viral loads exceeding 10(4) copies/μg DNA. Liver biopsy showed characteristic histopathological changes of EBV hepatitis and in situ hybridization with EBV-encoded RNA-1 was positive for EBV. Pancytopenia was detected in peripheral blood, and the bone marrow aspiration biopsy showed hypocellularity with replacement by adipocytes. AA progressed and the patient was treated with prednisolone but deceased 8 months after...Continue Reading

References

Jan 1, 1991·Clinical Microbiology Reviews·M OkanoD T Purtilo
Jan 1, 1989·Baillière's Clinical Haematology·G Kurtzman, N Young
Aug 17, 2000·The New England Journal of Medicine·J I Cohen
Dec 7, 2002·Critical Reviews in Oncology/hematology·Motohiko Okano
Feb 25, 2003·The Journal of Infectious Diseases·Hiroshi KimuraUNKNOWN Japanese Association for Research on Epstein-Barr Virus and Related Diseases
Sep 3, 2005·American Journal of Hematology·Motohiko OkanoShinsaku Imashuku
Mar 24, 2006·Journal of Hepatology·Uta DrebberHans P Dienes
Nov 27, 2008·Pediatric Transplantation·Jeffrey I Cohen
Nov 23, 2011·The American Journal of the Medical Sciences·Motohiko Okano, Thomas G Gross
Jan 1, 1986·Immunology Today·A B Rickinson

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Citations

Jun 25, 2016·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Seong Ran Jeon

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