A case of severe obstructive sleep apnoea in Madelung's disease treated by lateral pharyngoplasty

The Journal of Laryngology and Otology
V PintoOttavio Piccin

Abstract

Madelung's disease is a rare disorder characterised by the presence of multiple, symmetric, non-capsulated fat masses in the face, neck and other areas of upper extremities. In some cases, severe clinical complications such as upper airway compression can occur. A 56-year-old man affected by Madelung's disease complained of snoring and severe daytime sleepiness. Polysomnography revealed severe obstructive sleep apnoea. An attempt to treat sleep apnoea by continuous positive airway pressure failed because of poor compliance. Functional expansion pharyngoplasty was carried out as an initial treatment. Marked improvement of neck movements and normalisation of somnographic parameters were observed at six months' follow up. Patients with Madelung's disease should be examined carefully for potential obstructive sleep apnoea. Although continuous positive airway pressure remains the treatment of choice, specific surgery can be used in those patients who cannot tolerate continuous positive airway pressure therapy.

References

Jul 1, 1996·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·G D JosephsonJ Stern
Dec 30, 1998·Annals of Plastic Surgery·P D SmithR E Kearney
May 21, 2003·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·Jannis ConstantinidisHeinrich Iro
Dec 14, 2006·The Journal of Laryngology and Otology·S Ali, A Kishore
Oct 1, 2008·The Clinical Respiratory Journal·E JalladeauM F Vecchierini
Jun 26, 2010·Journal of Applied Physiology·Arie OlivenEitan Kimmel

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Citations

Jun 10, 2020·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Charnsiri Segsarnviriya, Naricha Chirakalwasan

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