A case of squamous cell carcinoma of the nasal cavity in a patient with granulomatosis with polyangiitis (Wegener granulomatosis)

Ear, Nose, & Throat Journal
Edward C KuanJoel A Sercarz

Abstract

We report a rare case of squamous cell carcinoma (SCC) of the nasal cavity arising in a patient with granulomatosis with polyangiitis (GPA). The patient was a 35-year-old man who had been diagnosed 15 years earlier with GPA and treated medically for sinonasal, pulmonary, and renal involvement. He presented to us with left-sided orbital and cheek pain and nasal obstruction. Endoscopy detected a friable, exophytic mass that involved the left lateral nasal wall and septum. Biopsy analysis identified the mass as an SCC. A definitive endoscopic resection was performed, followed by chemoradiation, but the patient exhibited progression of disease 2 months after the cessation of therapy. He then underwent an open craniofacial resection and a second round of chemoradiation. At 7 months of follow-up, he remained disease-free. Sinonasal symptoms in GPA are consistent with those in chronic rhinosinusitis, but the presence of unilateral symptoms may suggest a neoplastic process. Immunosuppressants are implicated in the pathophysiology of this malignancy, but equally plausible is the oncogenic role of chronic inflammation.

References

Mar 15, 1992·Annals of Internal Medicine·G S HoffmanA S Fauci
Dec 1, 1974·The Laryngoscope·T J McDonaldE G Harrison
Apr 1, 1980·The American Journal of Surgical Pathology·S B ChaskoG F Gray
Apr 5, 1995·Journal of the National Cancer Institute·L B TravisJ Adami
Mar 1, 1996·Annals of Internal Medicine·C Talar-WilliamsM C Sneller
Apr 22, 1999·Arthritis and Rheumatism·E TatsisW L Gross
Jun 19, 2001·Archives of Otolaryngology--head & Neck Surgery·J SteinG S Hoffman
Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·Ann KnightAnders Ekbom
Aug 9, 2003·Arthritis and Rheumatism·John H Stone, UNKNOWN Wegener's Granulomatosis Etanercept Trial Research Group
May 8, 2004·Annals of the Rheumatic Diseases·A KnightA Ekbom
Aug 19, 2004·Rheumatology·T PankhurstL Harper
Apr 29, 2006·Arthritis and Rheumatism·John H StoneUNKNOWN Wegener's Granulomatosis Etanercept Trial Research Group
Dec 1, 2007·Arthritis and Rheumatism·Olivier FainLoïc Guillevin
Jan 4, 2008·Clinical Reviews in Allergy & Immunology·Frank MoosigWolfgang L Gross
Mar 6, 2009·The Laryngoscope·Steven B CannadyGary S Hoffman
Feb 19, 2011·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Huseyin YamanAbdullah Belada
Mar 5, 2011·Annals of the Rheumatic Diseases·Ronald J FalkRichard Watts
Mar 19, 2011·The Journal of Craniofacial Surgery·Hasan Hüseyin ArslanMustafa Gerek
Apr 13, 2011·Arthritis and Rheumatism·Francisco SilvaUNKNOWN Wegener's Granulomatosis Etanercept Trial Research Group
Feb 4, 2014·Journal of Autoimmunity·Pamela M K Lutalo, David P D'Cruz
Aug 26, 2014·Autoimmunity Reviews·Cloé Comarmond, Patrice Cacoub

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
Shun-lai MiaoLi-juan Qi
© 2022 Meta ULC. All rights reserved