A case of ST elevation myocardial infarction secondary to heparin-induced thrombocytopaenia with thrombosis

Heart, Lung & Circulation
Clare ArnottSanjay Patel


A 54 year-old woman with Noonan Syndrome presented with an acute anterolateral ST elevation myocardial infarction two weeks post septal myectomy and heparin exposure, on the background of known normal coronary arteries. Coronary angiography revealed acute thrombosis of the left main, left anterior descending and left circumflex arteries, which was successfully treated by percutaneous coronary intervention with overlapping bare metal stents. A positive heparin induced platelet antibody test and dramatic fall in platelet count confirmed the diagnosis of heparin induced thrombocytopaenia with thrombosis (HITTS) as the underlying diagnosis. This represents the first documented case of HITTS induced left main coronary artery thrombosis and occlusion.


Dec 10, 2013·Heart, Lung & Circulation·Nicholas G KounisGeorge D Soufras
Jul 20, 2016·Journal of Cardiothoracic and Vascular Anesthesia·Aju P PazhenkottilDominique Bettex
Nov 8, 2016·International Heart Journal·Hiroshi OkamotoShiro Uemura


Feb 14, 1998·Radiographics : a Review Publication of the Radiological Society of North America, Inc·K D MurphyW J Garrisi
Sep 25, 2003·British Journal of Anaesthesia·R A Saad
Dec 5, 2006·Nature Genetics·Amy E RobertsRaju S Kucherlapati
Jan 29, 2011·Congenital Heart Disease·Edward J HickeyLee Benson

Related Concepts

Congenital Structural Myopathy
Arterial System
Neurologic Manifestations
Hypertrophic Cardiomyopathy
Stent, Device
Noonan Syndrome
Congenital, Hereditary, and Neonatal Diseases and Abnormalities

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