A Case of Streptozocin Monotherapy for Unresectable Duodenal Neuroendocrine Tumor G2

Case Reports in Oncology
Koji MiyagawaNobuaki Fuji

Abstract

Duodenal neuroendocrine tumors (NET) are rare, and few reports have demonstrated the effectiveness of chemotherapy for duodenal NET, with not many other treatment options available. Here, we present a case of unresectable duodenal NET G2 that was effectively treated with streptozocin (STZ) monotherapy. We also perform a literature review. A 57-year-old man presented with multiple lymph node metastasis, liver metastasis, and bone metastasis that occurred after the primary resection of the duodenal NET G2. His long-term survival was obtained; the duration of stable disease exceeded 1 year and 6 months following STZ monotherapy. In addition, his CA 19-9 levels, which previously were increasing, normalized following treatment. To our knowledge, no study has reported the effectiveness of STZ monotherapy for duodenal NET. Our findings demonstrate that for unresectable duodenal NETs, STZ should be first administered as a high volume/single dose to stabilize the disease. However, if the disease progresses, a combination therapy may be effective in obtaining a long-term prognosis of the patient. Furthermore, CA19-9 levels may be an effective factor for determining the therapeutic effect of STZ in NET with other metastases.

References

Nov 1, 1984·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P F EngstromH O Douglass
Jul 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Weijing SunUNKNOWN Eastern Cooperative Oncology Group
Jun 21, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James C YaoDouglas B Evans
Oct 15, 2008·Cancer·Oyvind HausoIrvin M Modlin
Sep 4, 2009·Endocrine-related Cancer·Laetitia DahanUNKNOWN Digestive Tumors Group of the Fédération Nationale des Centres de Lutte Contre le Cancer (FNCLCC)
Mar 18, 2010·British Journal of Cancer·N C TurnerT Meyer
Jan 5, 2014·The Lancet Oncology·Andrea FrillingUNKNOWN Working Group on Neuroendocrine Liver Metastases
Jan 22, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Tim MeyerPippa G Corrie

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