A case of synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome complicated by IgA nephropathy with nephrotic syndrome

CEN Case Reports
Katsuhiko MorimotoHideo Shiiki

Abstract

A 62-year-old man visited our hospital with a mild sore throat, high-grade fever, and clavicular pain. Seven years earlier, he had been diagnosed with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. His clavicles were tender and remarkably swollen. Also noted was marked pitting edema in the lower extremities and pustulosis on the palms and soles of the feet. Laboratory studies on admission showed an elevated white cell count (23,400/μl) and serum C-reactive protein level (24.4 mg/dl). Urinalysis revealed proteinuria (2+) and occult blood (3+) with numerous dysmorphic red blood cells and hyalin casts. The patient was diagnosed with recurrence of his SAPHO syndrome and started on oral glucocorticoid therapy. By day 9 after admission, he had gained 16 kg in body weight, and his proteinuria (6.4 g/day) and serum creatinine level (2.3 mg/dl) were elevated. Renal biopsy revealed mesangial proliferative glomerulonephritis with deposition of IgA and C3 in the mesangial area and along the capillary walls. The patient was diagnosed with IgA nephropathy accompanied by nephrotic syndrome. With oral prednisolone therapy, his fever, clavicular pain, and proteinuria were gradually relieved. The clinical course in thi...Continue Reading

References

Aug 1, 1989·The Journal of Laryngology and Otology·M FurukawaR Umeda
Jan 1, 1983·Acta Oto-laryngologica. Supplementum·T OnoN Kuriya
May 1, 1994·Baillière's Clinical Rheumatology·M F Kahn, M A Khan
Dec 12, 1997·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·R ValentinA Schaker
Jan 6, 2000·Seminars in Arthritis and Rheumatism·G HayemO Meyer
Sep 29, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·O HottaY Taguma
Apr 5, 2003·Kidney International·Yuansheng XieFumitake Gejyo
Mar 27, 2007·Clinical and Experimental Nephrology·Kenji NodaMasashi Suzuki
Mar 12, 2008·Current Opinion in Pediatrics·John T Sanders, Robert J Wyatt
Aug 30, 2008·Autoimmunity Reviews·Marcello GovoniFrancesco Trotta
Mar 21, 2009·Current Opinion in Nephrology and Hypertension·Candice A Roufosse, H Terence Cook
Jul 26, 2011·Clinical & Developmental Immunology·Yusuke SuzukiYasuhiko Tomino
Nov 29, 2013·The Journal of Dermatological Treatment·Wiggin WuWilson Liao
Dec 3, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Lin-Lin LiuXiao-Li Li

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Citations

Dec 24, 2018·Case Reports in Nephrology and Dialysis·Yoko FujitaYugo Shibagaki

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