A case of systemic lupus erythematosus complicated by pure red cell aplasia and idiopathic portal hypertension after thymectomy

Modern Rheumatology
Haruyo IwadateYukio Sato

Abstract

We describe a 49-year-old woman who presented in 2002 with pure red cell aplasia (PRCA), systemic lupus erythematosus (SLE), and idiopathic portal hypertension (IPH) that developed following a thymectomy. She underwent a thymectomy at 40 years of age to treat myasthenia gravis. PRCA developed 3 years after the thymectomy and she was successfully treated with cyclosporin. Systemic lupus erythematosus and IPH were diagnosed 6 years later. We conclude that immunological dysfunction resulting from the thymectomy contributed significantly to the subsequent development of PRCA, SLE, and IPH in this patient. This is the first report to describe this extremely rare occurrence.

References

Sep 1, 1995·International Archives of Allergy and Immunology·G Zandman-GoddardY Shoenfeld
Oct 1, 1994·Postgraduate Medical Journal·G VaiopoulosP Kaklamanis
Mar 28, 2001·Ryōikibetsu shōkōgun shirīzu·M Teramura

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Citations

Jan 8, 2010·Clinical and Experimental Nephrology·Hyder A OmarMahmoud Rezk-Abd-Elwahed Hussein
Feb 1, 2012·Clinical Journal of Gastroenterology·Hiromasa OhiraAtsushi Takahashi
May 17, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Kazumichi AbeHiromasa Ohira
May 17, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Manasi AgrawalThomas Schiano
Dec 19, 2017·Internal Medicine·Takashi IijimaYoshifumi Ubara
Aug 26, 2021·Rheumatology International·Alexandra KobzaCatherine Ivory

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