PMID: 8938559Nov 1, 1996Paper

A case of tizanidine-induced hepatic injury

Journal of Hepatology
E M de GraafB H Stricker

Abstract

The case history is presented of a woman who developed serious liver injury while taking 36 mg tizanidine daily. Other causes of hepatic injury were excluded. Symptoms resolved after discontinuation of tizanidine, and the liver enzyme levels were nearly normal 6 weeks after discontinuation of the drug. Rechallenge with 4 mg tizanidine caused a relapse. The temporal relationship between the symptoms and liver enzyme elevations, the absence of other potential causes, and the reaction to rechallenge, strongly implicate tizanidine as the cause of hepatic injury. As we are not aware of similar case histories, this seems to be the first reported case of tizanidine-induced hepatic injury.

References

Jan 1, 1983·European Journal of Clinical Pharmacology·V HeazlewoodM J Eadie

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Citations

Jan 3, 2008·Current Medical Research and Opinion·Leonard KamenJacob D Runyan
Aug 2, 2008·Expert Opinion on Pharmacotherapy·Gerard MalangaEdward Garay
Feb 26, 2019·Neurology. Neuroimmunology and Neuroinflammation·Mark StettnerSven G Meuth
Dec 16, 2020·Journal of Pharmacy Practice·John A Dougherty, Christopher T Elder
Aug 24, 2021·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Jorgina VilaImma Danés

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