A case of transient renal tubular acidosis type 1,4 hybrid RTA: a study of the pathophysiologic characteristics of the acidification defect

Pediatric Research
R A DonckerwolckeG J van Stekelenburg


The diagnosis of transient renal tubular acidosis was made in a 16 months old boy. Bicarbonate titration studies revealed that the acidification defect consisted of an association of proximal and distal tubular acidosis. The effect of experimentally induced potassium depletion revealed that hyperkalemia contributed to the acidification defect. After correction of the acidification disorder a defect in urinary concentration was still present.

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Acetazolamide Sodium, (Sterile)
Renal Tubular Acidosis, Type II
Carbonic Acid Ions
Hydrogen-Ion Concentration

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