A case of treatment-refractory psychosis responsive to sertindole

Schizophrenia Research
T D GeraciotiN M Richtand

Abstract

Sertindole is an antipsychotic with atypical in vitro and ex vivo binding profiles and little propensity to cause extrapyramidal symptoms. However, its potential usefulness in the treatment of psychosis resistant to the 'classical' neuroleptics has not been determined. In the present study we used a double blind, placebo-controlled trial of sertindole and observed dramatic, sustained resolution of formerly-chronic positive and negative psychotic symptoms in a schizophrenic patient. This patient had averaged 2.5 inpatient admissions per year for the 8 years preceding initiation of sertindole therapy, but has had no hospitalizations or psychosis in the 3.5 years since. Improved cognitive function has also been documented. This preliminary, but controlled, experience suggests that sertindole may possess a spectrum of clinical activity distinct from that of the typical antipsychotic agent.

Citations

Feb 24, 2001·Journal of Psychopharmacology·D M Taylor, D Duncan-McConnell
Jul 22, 2005·The Cochrane Database of Systematic Reviews·R LewisM Leitner

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