A case of treatment-resistant bipolar depression and comorbid OCD treated with deep brain stimulation of the medial forebrain bundle: 5 years follow-up results.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Lucio OldaniBernardo Dell'Osso

Abstract

Limited though promising evidence exists on the efficacy of Deep Brain Stimulation (DBS) of the Medial Forebrain Bundle (MFB) in otherwise intractable patients with Major Depression and Obsessive-Compulsive Disorder (OCD). Herein, we present acute and follow-up results (up to 5 years) of a 42 year old man with a diagnosis of treatment-resistant Bipolar Depression (BD) and comorbid OCD, successfully treated with DBS of the MFB. Regular follow-up visits with psychometric evaluations highlighted a considerable improvement of patient's depressive and OC symptoms at 5 years from implant. According to the limited, reported experience, we support the efficacy and tolerability of DBS of the MFB as a promising intervention in patients with treatment-resistant BD and comorbid OCD, with specific emphasis on the long-term outcome.

References

Sep 11, 2009·Acta Psychiatrica Scandinavica·I PacchiarottiE Vieta
Feb 12, 2010·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Thomas E SchlaepferUNKNOWN WFSBP Task Force on Brain Stimulation
Apr 9, 2013·Biological Psychiatry·Thomas E SchlaepferVolker A Coenen
Mar 15, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Volker A CoenenThomas E Schlaepfer

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