PMID: 11909876Mar 23, 2002Paper

A case-only approach for assessing gene by sex interaction in human longevity

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Q TanJ W Vaupel

Abstract

As one aspect of the complex feature of longevity, gene by sex interaction plays an important role in influencing human life span. With advances in molecular genetics, more studies aimed at assessing gene by sex interaction are expected. New and valid statistical methods are needed. In this article, we introduce a nontraditional approach, the case-only design, which was originally proposed for assessing gene and disease associations, to detect gene by sex interaction in human longevity. Applications of this method to data collected from centenarian studies show that it can produce consistent results as compared with results obtained from case-control and other approaches. The method cannot be used as a substitute for traditional case-control studies since it is limited to the detection of interactions only. However, the easily applicable case-only approach can be an important tool for screening many potential genes that contribute to human longevity.

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Citations

Mar 17, 2007·Population Studies·Siu Lan Karen Cheung, Jean-Marie Robine
Jan 14, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·John E Morley
Jan 21, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Naoko OkayamaYuji Hinoda
May 25, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Naoko OkayamaYuji Hinoda
Oct 12, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·M Elizabeth HodgsonRobert C Millikan
Nov 4, 2008·BMC Evolutionary Biology·Reinmar HagerJason B Wolf
Dec 13, 2005·Ageing Research Reviews·Qihua TanKaare Christensen
Oct 13, 2006·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Tomoko HashimotoYuji Hinoda

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