A case report of a spontaneous gastrointestinal stromal tumor (GIST) occurring in a F344 rat

Toxicologic Pathology
Hitoshi FujimotoMasao Hirose

Abstract

We report a case of gastrointestinal stromal tumor (GIST) that developed in a male F344 rat at week 101 of an experiment in a carcinogenicity study. Macroscopically, the primary tumor, which measured 1 cm in diameter, involved the submucosal tissue of the forestomach at the lesser curvature extending to the glandular stomach and esophagus. Histopathologically, the tumor was composed of neoplastic cells with small- to medium-sized spindle-shaped single nuclei and fibrillary cytoplasm lacking distinct cell borders. It invaded extensively into the tunica muscularis and subserosa, further extending to the lamina propria mucosa and serosal surface. A few densely proliferating portions showed a tendency to storiform pattern. Metastatic tumor nodules were found in the liver, spleen, and femur bone marrow, with multiple nodules, up to 1 cm in diameter, apparent in the liver. Immunohistochemically, diffuse, but weak cytoplasmic immunoreactivity for KIT was evident, and most neoplastic cells also exhibited strong immunoreactivity for a -smooth muscle actin and vimentin. Sparse nuclear S-100-immunoreactive cells were further observed, but none of neoplastic cells were immunoreactive for CD34, caldesmon, desmin, cytokeratin, or synaptophys...Continue Reading

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Citations

Apr 12, 2015·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Deanna D DaileyB E Powers
May 2, 2009·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Kathleen B MuravnickFabio Del Piero
Nov 11, 2009·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Anne Girard-LucFlorence Bernex
Sep 1, 2009·Journal of Toxicologic Pathology·Kaoru InoueAkiyoshi Nishikawa
Jan 3, 2020·Journal of Avian Medicine and Surgery·Peach Van WickErnesto Dominguez-Villegas
Mar 24, 2021·Journal of the American Veterinary Medical Association·Tatiane Terumi Negrão WatanabeRudy Bauer

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