PMID: 19940389Nov 27, 2009Paper

A case report of an uncommon sex-cord stromal tumor consisted of luteal and sertoli cells in a spayed bitch

The Journal of Veterinary Medical Science
Ryohei IchimuraKunitoshi Mitsumori

Abstract

We report a rare case of benign sex cord-stromal tumor consisted largely of luteoma with minor portion of Sertoli cell tumor located at the position of the left ovary excision in an 11-year-old ovariectomized bitch. Granulosa cell component was lacking, and both luteal and Sertoli cell portions were entirely positive for inhibin alpha and neuron-specific enolase, whereas luteoma portion alone was positive for Wilms' tumor-1 (WT1), immunohistochemically. The results suggest that this tumor is a possible complication of incomplete ovarian excision at the time of ovariectomy and consisted of uncommon hybrid of luteal and Sertoli cells to be diagnosed as an unclassified sex cord-stromal tumor if applied in human cases. WT1-expression pattern suggested the signature of the difference in the phenotype of these cell types.

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Citations

Jun 13, 2017·The Journal of Veterinary Medical Science·Osamu SakaiTakuya Mizuno
Aug 16, 2016·Journal of Veterinary Science·Daniel Maya-PulgarinJuan Guillermo Maldonado-Estrada

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