A case report of pseudoprogression followed by complete remission after proton-beam irradiation for a low-grade glioma in a teenager: the value of dynamic contrast-enhanced MRI.

Radiation Oncology
Candice MeyzerJacques Grill

Abstract

A fourteen years-old boy was treated post-operatively with proton therapy for a recurrent low-grade oligodendroglioma located in the tectal region. Six months after the end of irradiation (RT), a new enhancing lesion appeared within the radiation fields. To differentiate disease progression from radiation-induced changes, dynamic susceptibility contrast-enhanced (DSCE) MRI was used with a T2* sequence to study perfusion and permeability characteristics simultaneously. Typically, the lesion showed hypoperfusion and hyperpermeability compared to the controlateral normal brain. Without additional treatment but a short course of steroids, the image disappeared over a six months period allowing us to conclude for a pseudo-progression. The patient is alive in complete remission more than 2 years post-RT.

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Citations

Nov 16, 2012·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Amine M KorchiLaura Merlini
Apr 25, 2012·Journal of Neuro-oncology·Eric M ThompsonEdward A Neuwelt
Nov 13, 2012·Radiation Oncology·Henrik HauswaldStephanie E Combs
Nov 22, 2013·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Amine M KorchiDamien C Weber
Jul 24, 2012·AJNR. American Journal of Neuroradiology·N D SabinA Gajjar
Oct 24, 2012·Magnetic Resonance Imaging Clinics of North America·Jean-Christophe FerréMeng Law
Sep 15, 2015·Acta Oncologica·Yasmin Lassen-RamshadSusan L McGovern
Nov 21, 2012·Journal of Magnetic Resonance Imaging : JMRI·Blake E McGeheeJoseph A Maldjian
Jan 8, 2014·Journal of Magnetic Resonance Imaging : JMRI·Christophe VandendriesGuillaume Saliou
Feb 1, 2015·Pediatric Blood & Cancer·Kimberly A FosterRegina I Jakacki
Sep 13, 2014·Pediatric Blood & Cancer·Robert P NaftelRegina I Jakacki
Jun 9, 2015·Seminars in Radiation Oncology·Michael D Chan
May 15, 2016·Journal of Neuro-oncology·Sophie E M Veldhuijzen van ZantenUNKNOWN SIOPE DIPG Network
Sep 15, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sabine HeilandMartin Bendszus
Nov 22, 2014·The Cancer Journal·Bree R Eaton, Torunn Yock
Apr 9, 2015·Neurosurgery·Rohan RamakrishnaDaniel Silbergeld
May 20, 2020·Pediatric Blood & Cancer·Inês AlvesFernando Carceller
Jan 13, 2012·Journal of Neuro-oncology·Sheema ChawlaLouis S Constine
Jul 25, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Debarata BhattacharyaKshitij Mankad

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