PMID: 9545185Apr 17, 1998Paper

A case report of remarkable improvement of motor disturbances with L-dopa in a patient with post-diffuse axonal injury

Brain & Development
T Koeda, K Takeshita

Abstract

A 9-year-old girl with rigidospastic quadriplegia as post-traumatic sequela was reported. The distribution of lesions observed on a MRI implied diffuse axonal injury; involvement of the substantia nigra was also detected. L-Dopa administration was remarkably effective for relief of the rigidity. As a result, she became able to walk on her knees and communicate by writing letters. L-Dopa administration should be considered for patients who show rigidity as sequela of diffuse axonal injury with involvement of the substantia nigra.

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Citations

Dec 15, 2005·Neuropsychological Rehabilitation·Wakoto MatsudaAkira Matsumura
Apr 18, 2006·Lancet·James L Bernat
Feb 27, 2003·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Akira NakamizoMasashi Fukui
Nov 26, 2010·The Psychiatric Clinics of North America·Jaime M Levine, Steven R Flanagan

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