A case report of targeted therapy with apatinib in a patient with recurrent high grade glioma

Medicine
Xiuping DingBaosheng Li

Abstract

Despite the approval of antiangiogenic therapy for high grade glioma (HGG) patients, survival benefits are still limited. New treatment plans have always been developed to improve the survival. A 26-year-old woman was admitted to our hospital for distending pain of head and eye. Resonance imaging (MRI) revealed a large spherical heterogeneously enhancing, mixed cystic and solid mass in the right frontal region, and the midline shifted. The patient received apatinib therapy for positive vascular endothelial growth factor. A partial response was observed after 4 weeks and remains sustained until now. It suggests that apatinib might be a feasible option for the treatment in advanced HGG patients or patients with poor physical condition.

References

Jun 28, 2005·Journal of Neuropathology and Experimental Neurology·Hiroko Ohgaki, Paul Kleihues
Sep 24, 2005·Nature·Sara M Weis, David A Cheresh
Jul 24, 2007·Nature Reviews. Neuroscience·Rakesh K JainTracy T Batchelor
Dec 18, 2007·International Journal of Cancer. Journal International Du Cancer·An ClaesWilliam Leenders
Dec 18, 2009·BMC Cancer·Joost J C VerhoeffWouter R van Furth
Nov 7, 2013·JAMA : the Journal of the American Medical Association·Antonio Omuro, Lisa M DeAngelis
Jan 9, 2014·The Journal of International Medical Research·Chengyuan MaHaiyang Xu
Mar 15, 2014·International Journal of Oncology·Qingquan LiYingbin Li
Mar 23, 2015·Cancer Letters·Ivy PawHui-Wen Lo
Jan 23, 2016·Cancer Letters·Giandomenico RovielloDaniele Generali
Feb 20, 2016·Experimental and Therapeutic Medicine·Lei WangYinan Luo

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Citations

Jul 20, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Hui YaoYulun Huang

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xenograft
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