A case report of undifferentiated carcinoma with osteoclast-like giant cells of the pancreas and literature review

Clinical Journal of Gastroenterology
Yasuhiro TogawaAkihiro Toyoda

Abstract

Osteoclast-like giant cell tumors rarely arise in the pancreas. Here we report the case of a 78-year-old woman who was diagnosed with a well-defined 3 cm multilocular mass in the pancreatic body by the use of ultrasonography, computed tomography and magnetic resonance imaging. The rim and the septa of the tumor were well enhanced. The distal pancreas was removed with the spleen and the peripancreatic lymph nodes. Macroscopically, the mass was composed predominantly of a multilocular cystic tumor filled with hemorrhagic necrosis, and partly composed of solid components. A histopathological study showed a proliferation of multinucleated osteoclast-like giant cells and spindle cells. Although the predominant tumor cells were strongly positive for vimentin and CD68 and negative for epithelial markers, there were some sparsely scattered cytokeratin-positive neoplastic glands. Seventeen months after surgery, the patient is still alive and has had no recurrence. Below we review 32 cases of osteoclast-like giant cell tumor of the pancreas that have been reported in English literature since 2000.

References

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Citations

Jul 4, 2019·Journal of Medical Imaging and Radiation Oncology·Kousei IshigamiHiroshi Honda
Feb 6, 2020·Pancreas·Masahiro ShiiharaMasakazu Yamamoto
Jul 18, 2020·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Khoschy SchawkatKoenraad J Mortele
Sep 30, 2016·Archives of Pathology & Laboratory Medicine·Sarah L Rooney, Jiaqi Shi
Feb 19, 2015·International Surgery·Kazuhiko KitaguchiMasaru Konishi
Mar 23, 2021·Frontiers in Oncology·Pieter DemetterLaurine Verset

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