A case report of undifferentiated carcinoma with osteoclast-like giant cells of the pancreas and literature review

Clinical Journal of Gastroenterology
Yasuhiro TogawaAkihiro Toyoda


Osteoclast-like giant cell tumors rarely arise in the pancreas. Here we report the case of a 78-year-old woman who was diagnosed with a well-defined 3 cm multilocular mass in the pancreatic body by the use of ultrasonography, computed tomography and magnetic resonance imaging. The rim and the septa of the tumor were well enhanced. The distal pancreas was removed with the spleen and the peripancreatic lymph nodes. Macroscopically, the mass was composed predominantly of a multilocular cystic tumor filled with hemorrhagic necrosis, and partly composed of solid components. A histopathological study showed a proliferation of multinucleated osteoclast-like giant cells and spindle cells. Although the predominant tumor cells were strongly positive for vimentin and CD68 and negative for epithelial markers, there were some sparsely scattered cytokeratin-positive neoplastic glands. Seventeen months after surgery, the patient is still alive and has had no recurrence. Below we review 32 cases of osteoclast-like giant cell tumor of the pancreas that have been reported in English literature since 2000.


Mar 10, 2001·American Journal of Clinical Oncology·C C Leighton, D T Shum
May 17, 2002·Cancer·Christian WittekindLeslie H Sobin
Dec 21, 2002·International Journal of Clinical Oncology·Manabu ShiozawaYoshiaki Inayama
Jan 13, 2004·International Journal of Gastrointestinal Cancer·Eleni E CarvounisAgatha Paphitis
Apr 26, 2005·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Gisele A NaiMarcello Guilmar
May 28, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Markus KosmahlGünter Klöppel
Aug 27, 2005·Neurosurgical Focus·Thomas C OrigitanoBahman Emami
Dec 13, 2005·Acta Cytologica·Amobi M EzenekweT Brent Ponder
May 27, 2006·Journal of Gastroenterology and Hepatology·N Sautot-VialD Benchimol
Jan 5, 2007·World Journal of Gastroenterology : WJG·Juergen BauditzWolfram Wermke
Aug 31, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·J WeigtP Malfertheiner
Mar 13, 2008·Diagnostic Cytopathology·Lester J Layfield, Joel Bentz
May 22, 2008·Pathology Oncology Research : POR·George Burkadze, Gulisa Turashvili
Apr 16, 2009·Journal of Hepato-biliary-pancreatic Surgery·Yoshiki NaitoHirohisa Yano

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Jul 4, 2019·Journal of Medical Imaging and Radiation Oncology·Kousei IshigamiHiroshi Honda
Feb 6, 2020·Pancreas·Masahiro ShiiharaMasakazu Yamamoto
Jul 18, 2020·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Khoschy SchawkatKoenraad J Mortele
Sep 30, 2016·Archives of Pathology & Laboratory Medicine·Sarah L Rooney, Jiaqi Shi
Feb 19, 2015·International Surgery·Kazuhiko KitaguchiMasaru Konishi
Mar 23, 2021·Frontiers in Oncology·Pieter DemetterLaurine Verset

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