A Case Report on Primary Central Nervous System Lymphoma in Immunocompetent Individual.

Curēus
Shobha MandalJoyson Poulose

Abstract

Primary central nervous system lymphoma (PCNSL) is a rare form of CNS tumor. Immunosuppression is the most important risk factor of PCNSL, but few immunocompetent individuals are also affected. The most common clinical feature of PCNSL includes dizziness and ataxia. Our patient was a 71-year-old immunocompetent female who presented with progressive ataxia, imbalance, and dizziness for one year. A homogenous enhancing lesion was found in magnetic resonance imaging (MRI) of the head. One month later, on a follow-up MRI, a significant increase in the tumor size with surrounding edema was seen. The patient underwent craniotomy and resection of the mass. Subsequently, a diagnosis of diffuse large B cell lymphoma was made on pathology examination. Guideline-directed treatment options were discussed. This case highlights that the prognosis of patients with PCNSL highly depends on the factors such as age and physical status. Early diagnosis by accurate interpretation of imaging and management is crucial for better health outcomes.

References

Jan 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrés J M FerreriFranco Cavalli
Apr 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tamara N ShenkierJoseph M Connors
Jul 10, 2007·Acta Neuropathologica·David N LouisPaul Kleihues
May 20, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lilyana AngelovEdward A Neuwelt
Sep 22, 2009·Lancet·Andrés J M FerreriUNKNOWN International Extranodal Lymphoma Study Group (IELSG)
Jan 13, 2012·Progress in Neurological Surgery·Marilyn GatesSteven Kalkanis
Apr 17, 2012·Immunological Reviews·Katia Basso, Riccardo Dalla-Favera
Sep 18, 2012·Neuro-oncology·Michael WellerUNKNOWN German PCNSL Study Group
Nov 15, 2013·Rinshō shinkeigaku = Clinical neurology·Hideki NakajimaKuniko Abe
Apr 4, 2016·Clinical Radiology·G Bathla, A Hegde
Dec 4, 2016·Hematology·Tracy T Batchelor
Jul 13, 2018·Deutsches Ärzteblatt International·Louisa von BaumgartenMartin Dreyling
Nov 13, 2018·Neuro-oncology·Christian GrommesTracy T Batchelor
Jul 15, 2020·The Journal of International Medical Research·Xu ZengLigang Chen

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