A Case Series of Acquired Drug Resistance-Associated Mutations in Human Immunodeficiency Virus-Infected Children: An Emerging Public Health Concern in Rural Africa

Open Forum Infectious Diseases
Anna GamellEmilio Letang

Abstract

The acquisition of drug-resistance mutations among African children living with in human immunodeficiency virus on antiretroviral treatment has been scarcely reported. This threatens the overall success of antiretroviral programs and the clinical outcomes of children in care. We present a well characterized series of children from rural Tanzania with acquired drug-resistance mutations to contribute to the better understanding of this emerging public health concern.

References

Mar 21, 2002·The Lancet Infectious Diseases·Annemarie M C van RossumRonald de Groot
Sep 9, 2004·AIDS·A Sarah WalkerUNKNOWN Collaborative HIV Paediatric Study (CHIPS) Steering Committee
Jan 6, 2006·The Pediatric Infectious Disease Journal·Paul J WeidleMark W Kline
May 20, 2006·BMJ : British Medical Journal·Esse N MensonUNKNOWN Collaborative HIV Paediatric Study Steering Committee
Jul 11, 2008·AIDS·UNKNOWN Collaboration of Observational HIV Epidemiological Research Europe (COHERE) Study GroupJens Lundgren
Jul 26, 2008·The Lancet Infectious Diseases·Catherine G SutcliffeWilliam J Moss
Jun 26, 2010·The Journal of Antimicrobial Chemotherapy·Clara BratholmJohan N Bruun
Dec 1, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Dalton C WamalwaJulie Overbaugh
Jun 29, 2013·AIDS Research and Human Retroviruses·Pax MasimbaIngrid Felger
Jul 12, 2014·The New England Journal of Medicine·Nicholas I PatonUNKNOWN EARNEST Trial Team

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