A case series of inactivated Japanese encephalitis virus vaccination associated with positive West Nile virus blood donor screening nucleic acid tests

Transfusion
Steven J DrewsMark Bigham

Abstract

West Nile Virus (WNV) is a member of the Japanese Encephalitis (JE) serocomplex within the Flaviviridae family. We report four whole blood donors and one plasma donor with WNV nucleic acid test (NAT)-reactive donations between September 2018 and November 2019, following recent Japanese Encephalitis virus (JEV) vaccination. Cases 1 and 4 had reactive WNV NAT donations 1 day after receiving the JEV vaccine. Case 2 had a reactive WNV donation 3 days after receiving the JEV vaccine. Case 3 had a reactive WNV NAT donation 3 days after returning from Arizona and 1 day after receiving the JEV vaccine. Case 5 had a reactive WNV donation the same day as receiving the JEV vaccine. WNV screening used the Roche cobas WNV nucleic acid test (NAT) (Roche Molecular Systems). Reference testing on WNV-reactive donations was carried out by the National Microbiology Laboratory (NML). JEV vaccine dilutions were also analyzed. Supplemental NAT was negative for WNV and JEV for Cases 1, 3, and 5. Case 2 had a weak amplification curve for one of two JEV NAT targets. Case 4 was JEV NAT-positive, WNV NAT-negative. Serologic testing on donation specimens for Cases 2, 4, and 5 did not support recent or remote WNV infection. JEV vaccine dilutions were detec...Continue Reading

References

Sep 1, 1958·The American Journal of Tropical Medicine and Hygiene·D H CLARKE, J CASALS
Mar 20, 2004·Emerging Infectious Diseases·Shannon L EmeryLarry J Anderson
May 3, 2006·Journal of Virological Methods·M AyersR Tellier
Jul 4, 2007·Journal of Medical Virology·Jeffrey M LinnenCristina Giachetti
Aug 30, 2008·The Journal of Infectious Diseases·Michael P BuschSally Caglioti
Feb 9, 2012·Expert Review of Vaccines·Mario Lobigs, Michael S Diamond
Apr 24, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·H ZellerE Warns-Petit
Jan 27, 2015·Human Vaccines & Immunotherapeutics·Christa Firbas, Bernd Jilma
Dec 15, 2015·MMWR. Morbidity and Mortality Weekly Report·Heather VenkatSusan Hills
Sep 7, 2016·Journal of Medical Entomology·Andrew C ChaulkThomas W Chapman
Oct 19, 2017·Emerging Infectious Diseases·Vincent C C ChengKwok-Yung Yuen
Nov 1, 2018·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Stephan W AberleNorbert Nowotny
Jul 5, 2019·Transfusion·Hans L ZaaijerMarco H G M Koppelman

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