A case series of Kimura's disease: a diagnostic challenge

Therapeutic Advances in Hematology
Vivek KumarYiqing Xu

Abstract

Kimura's disease (KD) is a rare, benign disorder characterized by subcutaneous masses with regional lymph-node enlargement. It is considered to be due to chronic inflammation of unclear etiology. Most cases have been reported in young, 20-30-year-old men of Asian descent. The diagnosis of KD is based on pathological features and elevated immunoglobulin E levels. Characteristic pathological features include intact lymph-node architecture, florid germinal center hyperplasia, extensive eosinophilic infiltrates, and proliferation of postcapillary venules. However, these features can also be seen in Hodgkin's disease or T-cell lymphoma, therefore, cases presenting as KD pose a diagnostic challenge. We report a case series of two cases with suspected KD at initial presentation, with one patient eventually diagnosed with Hodgkin's disease after clinical progression. The first case was a 45-year-old Asian man who presented with bilateral thigh masses and significantly enlarged inguinal lymph nodes. The histopathology was characteristic and the patient had stable disease on treatment with cetirizine for 20 months. The second case was a 29-year-old African-American man who had progressive enlargement of the right neck lymph nodes extendi...Continue Reading

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Citations

Dec 5, 2019·QJM : Monthly Journal of the Association of Physicians·E KakehiM Matsumura
Sep 2, 2020·Chinese Medical Journal·Tao WangZhi-Jun Li
Jan 4, 2020·BMC Surgery·Guoliang ZhangWeidong Qi
Oct 30, 2020·Therapeutic Advances in Hematology·Eiichi KakehiMasami Matsumura
Feb 9, 2021·Radiologic Clinics of North America·Patrick P Bourgouin, Rachna Madan

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Methods Mentioned

BETA
biopsy
X-ray

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