A case series of lacosamide as adjunctive therapy in refractory sleep-related hypermotor epilepsy (previously nocturnal frontal lobe epilepsy)

Journal of Sleep Research
Shanika R SamarasekeraIngrid E Scheffer

Abstract

The aim of this study was to evaluate the efficacy and tolerability of open-label lacosamide in patients with refractory sleep-related hypermotor epilepsy. The study was a case review of eight patients with refractory sleep-related hypermotor epilepsy treated with lacosamide. Seizure diaries compared the mean baseline seizure frequency with the most recent 3 months of follow-up. Five (62.5%) patients were responders, defined as ≥50% reduction in seizure frequency, over a mean duration of exposure of 21.5 months. The mean maintenance dose of lacosamide was 400 mg/day. No-one reported worsening of seizures. Lacosamide was well tolerated with initial fatigue being the main side-effect. Lacosamide is a potentially efficacious adjunctive therapy in patients with refractory sleep-related hypermotor epilepsy. A double-blind placebo-controlled study would determine its efficacy.

References

Feb 1, 1995·Brain : a Journal of Neurology·I E SchefferF Cendes
Jun 4, 1999·Brain : a Journal of Neurology·F ProviniP Montagna
Mar 1, 2012·Epilepsy & Behavior : E&B·Vicente VillanuevaConsuelo Santafé
Apr 12, 2016·Epilepsy & Behavior : E&B·Giuseppe BorzìAngelo Labate
May 11, 2016·Neurology·Paolo TinuperRuth Ottman

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Citations

Oct 16, 2018·Frontiers in Pharmacology·Jaya KumarSrijit Das
Jan 31, 2020·Current Treatment Options in Neurology·Gian Maria AsioliFederica Provini

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