A case study for online plan adaptation using helical tomotherapy.

Journal of Medical Physics
Christopher E Neilson, S Yartsev

Abstract

Helical tomotherapy's ability to provide daily megavoltage (MV) computed tomography (CT) images for patient set-up verification allows for the creation of adapted plans. As plans become more complex by introducing sharper dose gradients in an effort to spare healthy tissue, inter-fraction changes of organ position with respect to plan become a limiting factor in the correct dose delivery to the target. Tomotherapy's planned adaptive option provides the possibility to evaluate the dose distribution for each fraction and subsequently adapt the original plan to the current anatomy. In this study, 30 adapted plans were created using new contours based on the daily MVCT studies of a bladder cancer patient with considerable anatomical variations. Dose to the rectum and two planning target volumes (PTVs) were compared between the original plan, the dose that was actually delivered to the patient, and the theoretical dose from the 30 adapted plans. The adaptation simulation displayed a lower dose to 35% and 50% of the rectum compared to no adaptation at all, while maintaining an equivalent dose to the PTVs. Although online adaptation is currently too time-consuming, it has the potential to improve the effectiveness of radiotherapy.

References

Jan 1, 1997·Physics in Medicine and Biology·D YanA Martinez
Dec 14, 2004·International Journal of Radiation Oncology, Biology, Physics·Lisa J ForrestMinesh P Mehta
Nov 1, 2005·International Journal of Radiation Oncology, Biology, Physics·Eric K HansenPing Xia
Feb 1, 2006·International Journal of Radiation Oncology, Biology, Physics·Chester R RamseyRebecca M Seibert
Feb 27, 2007·International Journal of Radiation Oncology, Biology, Physics·Glenn BaumanJake Van Dyk
Mar 14, 2007·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Jason P SmithJonathan D Kaunitz
Oct 31, 2007·International Journal of Radiation Oncology, Biology, Physics·Curtis WoodfordJake Van Dyk
Nov 24, 2007·Nature Reviews. Cancer·Dirk VerellenGuy Storme
Sep 10, 2008·Medical Physics·Ergun E AhunbayX Allen Li
Aug 4, 2009·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·James RenaudJake Van Dyk
Oct 6, 2009·International Journal of Radiation Oncology, Biology, Physics·Qiuwen WuAlvaro Martinez
Jul 14, 2010·International Journal of Radiation Oncology, Biology, Physics·Peter H AhnMadhur K Garg
Feb 3, 2011·Physics in Medicine and Biology·Taoran LiQ Jackie Wu
Mar 1, 2011·Clinical Oncology : a Journal of the Royal College of Radiologists·P OstG De Meerleer
May 26, 2011·The Cancer Journal·Qingrong Jackie WuFang-Fang Yin
May 31, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Shaun TolanPeter Chung
Jun 1, 2011·Frontiers of Radiation Therapy and Oncology·Patrick Kupelian, Katja Langen
Jun 1, 2011·Frontiers of Radiation Therapy and Oncology·Patrick Kupelian, John L Meyer
Jul 5, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Pierre CastadotVincent Grégoire
Sep 3, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Agathe Edet-SansonPierre Vera

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TomoTherapy Planned Adaptive ®
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TomoTherapy Planning Station
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