A catechin-enriched green tea extract prevents glucose-induced survival reduction in Caenorhabditis elegans through sir-2.1 and uba-1 dependent hormesis

Fitoterapia
Dorothé Jenni DeusingElena Fitzenberger

Abstract

Hyperglycemia is a hallmark of diabetes mellitus which leads to the onset of complications in the long term. Green tea through its high content of polyphenolic catechins, on the other hand, is suggested to prevent or at least delay such detrimental complications. In the present study we fed the nematode Caenorhabditis elegans on a liquid medium supplemented with 10mM glucose in the absence or presence of a catechin-enriched green tea extract (CEGTE). After exposure of young adults for 48h survival was subsequently measured under heat stress at 37°C. Whereas CEGTE at 0.01% did not affect the survival of wild type nematodes, it completely reversed the glucose-induced survival reduction. Those effects were not achieved through the monomeric catechins included in CEGTE. RNA interference (RNAi) for sir-2.1 not only prevented the survival extension by CEGTE under simultaneous glucose exposure but also caused a further reduction of survival. Likewise, the knockdown of uba-1, encoding the only E1-ubiquitin-activating enzyme in C. elegans, proved that UBA-1 is essential for the survival extension by CEGTE and that its loss of function changes CEGTE from a survival extending into a survival reducing extract. Stimulation of the proteasome...Continue Reading

References

Oct 10, 1997·Journal of the American College of Nutrition·H G Preuss
Jul 16, 2002·The Journal of Biological Chemistry·Mary E Waltner-LawDaryl K Granner
Aug 27, 2003·Nature·Konrad T HowitzDavid A Sinclair
Sep 6, 2003·Free Radical Biology & Medicine·Matthew S GillGordon J Lithgow
Jun 29, 2006·Journal of Nutritional Science and Vitaminology·Kenjiro TaderaTomoko Matsuoka
Jul 25, 2006·Chemico-biological Interactions·Pon Velayutham Anandh BabuChennam Srinivasulu Shyamaladevi
Dec 19, 2006·Cell Cycle·Ala Berdichevsky, Leonard Guarente
Oct 2, 2007·Journal of the American College of Nutrition·Swen Wolfram
Apr 30, 2008·Journal of Agricultural and Food Chemistry·Tahira SultanaGuenther Karl Bonn
May 13, 2008·BMC Developmental Biology·Johanna PispaJussi Jäntti
May 16, 2008·Human & Experimental Toxicology·Mark P Mattson
Jul 29, 2009·Mediators of Inflammation·Jun-ichi SuzukiRyozo Nagai
Aug 18, 2009·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Niels Boon
Dec 17, 2009·Diabetes·Markus A QueisserKlaus T Preissner
Apr 13, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·S Abbas, M Wink
May 11, 2010·Archives of Biochemistry and Biophysics·Sangwoon ChungIrfan Rahman
Jun 19, 2010·Archives of Biochemistry and Biophysics·Joshua D Lambert, Ryan J Elias
Aug 19, 2010·Planta medica·Tadahiro SunagawaTakuji Shirasawa
Sep 24, 2011·American Journal of Physiology. Cell Physiology·Charles S HummelErnest M Wright
Oct 25, 2011·Molecular Aspects of Medicine·Vittorio CalabreseEdward J Calabrese
Nov 8, 2011·Diabetes Research and Clinical Practice·Louis MonnierDavid Owens
Feb 15, 2012·Free Radical Biology & Medicine·Jingqi YanBaolu Zhao
Nov 28, 2012·Molecular Nutrition & Food Research·Gary Williamson
Dec 12, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Wei ChenMichael Wink
Mar 2, 2013·Current Pharmaceutical Design·Naghma Khan, Hasan Mukhtar
Aug 14, 2013·Journal of Diabetes and Metabolic Disorders·Zahra BahadoranFereidoun Azizi
Sep 27, 2013·Oxidative Medicine and Cellular Longevity·Kathrin PallaufGerald Rimbach

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Citations

Oct 13, 2015·Food & Function·Kaige JiKun Huang
Sep 10, 2016·The Proceedings of the Nutrition Society·Kathrin PallaufGerald Rimbach
May 23, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qiu-Yue FuYue-Rong Liang
Dec 19, 2020·Comprehensive Reviews in Food Science and Food Safety·Yongli YeXiulan Sun

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