A catechol antioxidant protocatechuic acid potentiates inflammatory leukocyte-derived oxidative stress in mouse skin via a tyrosinase bioactivation pathway

Free Radical Biology & Medicine
Y NakamuraHajime Ohigashi

Abstract

The modifying effects of topical application of a catechol antioxidant protocatechuic acid (PA) on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammatory responses in mouse skin were investigated. Treatment with a high dose (20,000 nmol) of PA, based on time of application, modifies inflammatory responses in the skin of the B6C3F(1) mouse, a resistant strain to inflammatory response induction by TPA, but shows much higher tyrosinase expression than that of an albino mouse. The responsibility of a large amount of PA-induced leukocyte infiltration to an inflamed region in a B6C3F(1) mouse is more sensitive than that of an ICR albino mouse. When ICR mice were treated with TPA (1.6 nmol) twice weekly for 5 weeks to induce chronic inflammatory responses, pretreatment with 1600 nmol PA 30 min prior to each TPA treatment significantly enhanced the inflammatory responses including edema formation, leukocyte infiltration, and the level of thiobarbituric acid-reacting substances. The dose-dependency was closely parallel to the results of a tumor promotion study of PA previously reported. Further, the treatment of PA alone resulted in tyrosinase-dependent contact hypersensitivity in ICR mouse skin. In addition, the in vitro study...Continue Reading

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Citations

Jul 13, 2011·Inflammopharmacology·Amol B LendeSuresh R Naik
Dec 25, 2010·Journal of Medicinal Food·Jaouad AnterAndrés Muñoz-Serrano
Feb 9, 2010·Bioscience, Biotechnology, and Biochemistry·Yoshimasa Nakamura, Noriyuki Miyoshi
Oct 23, 2014·Journal of Cancer Prevention·Hyun-Jeong KimKwang-Kyun Park
Dec 26, 2001·The Journal of Biological Chemistry·Yoshimasa NakamuraKoji Uchida
Oct 20, 2001·The Journal of Biological Chemistry·Eng-Kiat LimDianna J Bowles
Jan 24, 2002·Journal of Agricultural and Food Chemistry·Shengmin SangChi-Tang Ho
Oct 27, 2010·Journal of Natural Products·Tzung-Han ChouChia-Hua Liang

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