A Cathepsin-L is required for invasive behavior during Air Sac Primordium development in Drosophila melanogaster

FEBS Letters
Qian DongAjay Srivastava

Abstract

The Drosophila Air Sac Primordium (ASP) has emerged as an important structure where cellular, genetic and molecular events responsible for invasive behavior and branching morphogenesis can be studied. In this report we present data which demonstrate that a Cathepsin-L encoded by the gene CP1 in Drosophila is necessary for invasive behavior during ASP development. We find that CP1 is expressed in ASP and knockdown of CP1 results in suppression of migratory and invasive behavior observed during ASP development. We further show that CP1 possibly regulates invasive behavior by promoting degradation of Basement Membrane. Our data provide clues to the possible role of Cathepsin L in human lung development and tumor invasion, especially, given the similarities between human lung and Drosophila ASP development.

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Citations

Jul 19, 2018·International Journal of Molecular Sciences·Nathan Powers, Ajay Srivastava
Oct 4, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·David E Surate SolaligueRory E Morty
Jul 10, 2019·Communications Biology·Kristen M LeeMike Grotewiel
Jan 12, 2020·Communications Biology·Kristen M LeeMike Grotewiel

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