A causal link between oxidative stress and inflammation in cardiovascular and renal complications of diabetes

Clinical Science
Jay C JhaKarin Jandeleit-Dahm

Abstract

Chronic renal and vascular oxidative stress in association with an enhanced inflammatory burden are determinant processes in the development and progression of diabetic complications including cardiovascular disease (CVD), atherosclerosis and diabetic kidney disease (DKD). Persistent hyperglycaemia in diabetes mellitus increases the production of reactive oxygen species (ROS) and activates mediators of inflammation as well as suppresses antioxidant defence mechanisms ultimately contributing to oxidative stress which leads to vascular and renal injury in diabetes. Furthermore, there is increasing evidence that ROS, inflammation and fibrosis promote each other and are part of a vicious connection leading to development and progression of CVD and kidney disease in diabetes.

References

Jan 17, 1995·Proceedings of the National Academy of Sciences of the United States of America·Z S GalisP Libby
Oct 1, 1995·Journal of Diabetes and Its Complications·H MakinoZ Ota
May 1, 1996·Cardiology Clinics·A P Schroeder, E Falk
Oct 1, 1996·Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·M KanauchiK Dohi
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·F M Yakes, B Van Houten
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·K Chan, Y W Kan
Mar 23, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·R A RodbyE J Lewis
Sep 9, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·T NakamuraH Koide
Feb 13, 2001·Kidney International·C Guijarro, J Egido
Feb 13, 2001·Kidney International. Supplement·J GalleK Heermeier
Mar 22, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·L SchaeferH Kresse
Sep 22, 2001·The New England Journal of Medicine·E J LewisUNKNOWN Collaborative Study Group
Sep 22, 2001·The New England Journal of Medicine·B M BrennerUNKNOWN RENAAL Study Investigators
Sep 22, 2001·The New England Journal of Medicine·H H ParvingUNKNOWN Irbesartan in Patients with Type 2 Diabetes and Microalbuminuria Study Group
Jan 12, 2002·Kidney International·Maristela Lika OnozatoChristopher S Wilcox
May 29, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jan Henrik HörstrupKai-Uwe Eckardt
Jul 9, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Fuad S ShihabTakeshi F Andoh
Dec 18, 2002·Experimental Biology and Medicine·Jingfei Cheng, Joseph P Grande
Apr 23, 2003·Journal of the American Society of Nephrology : JASN·Roger M Mason, Nadia Abdel Wahab
May 16, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Roberto Pecoits-FilhoPeter Stenvinkel
Jul 8, 2003·The Journal of Pathology·Effie C Tsilibary
Jul 23, 2003·Journal of the American Society of Nephrology : JASN·Hi Bahl LeeHunjoo Ha
Jul 29, 2003·Diabetes Care·Berthold AmannBernhard Angelkort
Sep 6, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shaw-Fang YetMark A Perrella
Nov 11, 2003·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Dilek YavuzSema Akalin
Apr 23, 2004·Journal of Clinical Laboratory Analysis·Kyoichi TashiroYasuhiko Tomino
Dec 1, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Helena C F OliveiraAníbal E Vercesi
Jan 11, 2005·The Journal of Pharmacy and Pharmacology·Yaxian DingChung-Ho Chang

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Citations

Apr 6, 2019·Inhalation Toxicology·Fadia Mayyas, Karem H Alzoubi
Jul 25, 2019·Diabetic Medicine : a Journal of the British Diabetic Association·J SeyfarthJ Rosenbauer
Dec 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hiroshi Kitamura
Jul 9, 2020·Toxins·Gerald Cohen
Jan 2, 2019·International Journal of Molecular Sciences·Ming-Tsun Tsai, Der-Cherng Tarng
Aug 18, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tengis S PavlovAlexander Staruschenko
May 25, 2020·Journal of Nephrology·Jakob Appel ØstergaardKarin Agnes Maria Jandeleit-Dahm
Sep 12, 2020·Antioxidants·Patricia Fernandez-RobredoAlfredo Garcia-Layana
Nov 15, 2019·Molecular and Cellular Biochemistry·Emma HarperPhilip M Cummins
Mar 14, 2021·Physiological Reports·Michael D WetzelAlaa S Awad
Apr 23, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Chu-Ting HuChi Zhang
May 15, 2021·Frontiers in Pharmacology·Ker Woon ChoyMohd Rais Mustafa
Aug 6, 2021·Acta Pharmacologica Sinica·Ning CaoEr-Dan Dong

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