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A causal role for TRESK loss of function in migraine mechanisms

Brain : a Journal of Neurology

Nov 20, 2019

Philippa PettingillM Zameel Cader

Abstract

The two-pore potassium channel, TRESK has been implicated in nociception and pain disorders. We have for the first time investigated TRESK function in human nociceptive neurons using induced pluripotent stem cell-based models. Nociceptors from migraine patients with the F139WfsX2 mutati...read more

Mentioned in this Paper

Pathogenesis
Pluripotent Stem Cells
Membrane
Migraine Disorders
Nitroglycerin
KCNK2
Potassium Channel
Tissue Engineering
Nociceptors
Rodent
19
4
Paper Details
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A causal role for TRESK loss of function in migraine mechanisms

Brain : a Journal of Neurology

Nov 20, 2019

Philippa PettingillM Zameel Cader

PMID: 31742594

DOI: 10.1093/brain/awz342

Abstract

The two-pore potassium channel, TRESK has been implicated in nociception and pain disorders. We have for the first time investigated TRESK function in human nociceptive neurons using induced pluripotent stem cell-based models. Nociceptors from migraine patients with the F139WfsX2 mutati...read more

Mentioned in this Paper

Pathogenesis
Pluripotent Stem Cells
Membrane
Migraine Disorders
Nitroglycerin
KCNK2
Potassium Channel
Tissue Engineering
Nociceptors
Rodent
19
4

Similar Papers Found In These Feeds

Related Papers

Paper Details
References
  • References37
  • Citations
1234
  • References37
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.
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