A cautionary note on the use of simulation procedures for analyzing contingency tables containing small expected cell frequencies

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Jaime R Robles, Edwin J C G van den Oord

Abstract

A comparison of a simple simulation procedure and exact tests for tables used in psychiatric genetic studies is performed, with focus on tables with small expected cell counts. The study shows that naive simulation procedures using uniform random numbers, could lead to conservative results, as compared with Fisher exact test for contingency tables, thus discarding as non-significant tables that are significant according to the exact test. Exact tests are recommended as an alternative to naive simulation for evaluating the statistical significance of contingency tables with small expected cell counts.

References

Oct 5, 2001·Nature Genetics·G C JohnsonJ A Todd
Jul 12, 2002·American Journal of Human Genetics·B V NorthP C Sham
Aug 23, 2003·Biostatistics·Alan Agresti, Yongyi Min
Mar 23, 2004·Biometrics·Eric-Jan WagenmakersRoger Ratcliff
Jun 8, 2004·Bioinformatics·Jaime R Robles, Edwin J C G van den Oord
Oct 14, 2004·Genetic Epidemiology·David ClaytonJason Cooper

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