PMID: 3757032Sep 26, 1986Paper

A CCAAT box confers cell-type-specific regulation on the Xenopus hsp70 gene in oocytes

Cell
M Bienz

Abstract

The Xenopus hsp70 gene is transiently heat-inducible in somatic cells; in injected oocytes, it is efficiently expressed without heat shock. I show here that this cell-type-specific and gene-specific activation is dependent on the presence of a heat shock regulatory element (HSE) and a CCAAT box in the hsp70 promoter; neither element by itself is sufficient for full activation. The same promoter elements are also required for heat inducibility in somatic cells. I propose that CAAT-binding transcription factor (CTF) interacts with heat shock transcription factor (HSTF), thereby enhancing the affinity of HSTF for the promoter; cell-type specificity could be explained by assuming either oocyte-specific forms or oocyte-specific high levels of CTF and/or HSTF.

References

Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·B J WuR I Morimoto
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·B J Wu, R I Morimoto
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M Bienz

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Citations

Jan 1, 1990·The International Journal of Biochemistry·J J Heikkila
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