A CD2 high-expressing stress-resistant human plasmacytoid dendritic-cell subset

Immunology and Cell Biology
Christian BryantDerek Nj Hart

Abstract

Human plasmacytoid dendritic cells (pDCs) were considered to be a phenotypically and functionally homogeneous cell population; however, recent analyses indicate potential heterogeneity. This is of major interest, given their importance in the induction of anti-viral responses and their role in creating immunologically permissive environments for human malignancies. For this reason, we investigated the possible presence of human pDC subsets in blood and bone marrow, using unbiased cell phenotype clustering and functional studies. This defined two major functionally distinct human pDC subsets, distinguished by differential expression of CD2. The CD2(hi) and CD2(lo) pDCs represent discontinuous subsets, each with hallmark pDC functionality, including interferon-alpha production. The rarer CD2(hi) pDC subset demonstrated a significant survival advantage over CD2(lo) pDC during stress and upon exposure to glucocorticoids (GCs), which was associated with higher expression of the anti-apoptotic molecule BCL2. The differential sensitivity of these two human pDC subsets to GCs is demonstrated in vivo by a relative increase in CD2(hi) pDC in multiple myeloma patients treated with GCs. Hence, the selective apoptosis of CD2(lo) pDC during ...Continue Reading

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Citations

Feb 24, 2018·Immunology and Cell Biology·Regine J DressFlorent Ginhoux
Jan 10, 2018·Immunology·Matthew Collin, Venetia Bigley
Jun 6, 2018·Immunology and Cell Biology·Casper MarsmanJoanna R Groom
Nov 22, 2019·Journal of Leukocyte Biology·Phillip D FrommGeorgina J Clark
May 31, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pratik DebPatricia Fitzgerald-Bocarsly
Jun 14, 2019·Frontiers in Immunology·Andrea MusumeciAnne Barbara Krug
Jun 4, 2019·Frontiers in Immunology·Jake William RhodesStuart Grant Turville
Nov 5, 2019·Frontiers in Immunology·Helong DaiNatasha M Rogers
Jul 1, 2020·Immunological Investigations·Samaneh SoltaniElham Farhadi
Feb 9, 2017·Proceedings of the National Academy of Sciences of the United States of America·Hong ZhangEdgar G Engleman
Jun 4, 2020·Clinical & Translational Immunology·Yishan YeFlorent Malard

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